diff --git a/core/src/components/item-sliding/item-sliding.tsx b/core/src/components/item-sliding/item-sliding.tsx
index d2bce0e0dfd..d3272a620ae 100644
--- a/core/src/components/item-sliding/item-sliding.tsx
+++ b/core/src/components/item-sliding/item-sliding.tsx
@@ -408,6 +408,11 @@ export class ItemSliding implements ComponentInterface {
     if (this.tmr !== undefined) {
       clearTimeout(this.tmr);
       this.tmr = undefined;
+      // Reopening cancels the close animation, including its interaction cleanup.
+      this.el.classList.remove('item-sliding-closing');
+      if (this.gesture) {
+        this.gesture.enable(!this.disabled);
+      }
     }
     if (!this.item) {
       return;
diff --git a/core/src/components/item-sliding/test/open/index.html b/core/src/components/item-sliding/test/open/index.html
new file mode 100644
index 00000000000..32e42bc234e
--- /dev/null
+++ b/core/src/components/item-sliding/test/open/index.html
@@ -0,0 +1,40 @@
+<!DOCTYPE html>
+<html lang="en" dir="ltr">
+  <head>
+    <meta charset="UTF-8" />
+    <title>Item Sliding - Switching Sides</title>
+    <meta name="viewport" content="width=device-width, initial-scale=1.0" />
+    <link href="../../../../../css/ionic.bundle.css" rel="stylesheet" />
+    <link href="../../../../../scripts/testing/styles.css" rel="stylesheet" />
+    <script src="../../../../../scripts/testing/scripts.js"></script>
+    <script nomodule src="../../../../../dist/ionic/ionic.js"></script>
+    <script type="module" src="../../../../../dist/ionic/ionic.esm.js"></script>
+  </head>
+  <body>
+    <ion-app>
+      <ion-content>
+        <p>
+          Open one side, then the other. The new option should remain clickable and the item should still swipe closed.
+        </p>
+        <button onclick="document.querySelector('ion-item-sliding').open('start')">Open start</button>
+        <button onclick="document.querySelector('ion-item-sliding').open('end')">Open end</button>
+        <ion-list>
+          <ion-item-sliding>
+            <ion-item><ion-label>Sliding item</ion-label></ion-item>
+            <ion-item-options side="start">
+              <ion-item-option onclick="document.querySelector('output').textContent = 'Start clicked'"
+                >Start</ion-item-option
+              >
+            </ion-item-options>
+            <ion-item-options side="end">
+              <ion-item-option onclick="document.querySelector('output').textContent = 'End clicked'"
+                >End</ion-item-option
+              >
+            </ion-item-options>
+          </ion-item-sliding>
+        </ion-list>
+        <output aria-live="polite"></output>
+      </ion-content>
+    </ion-app>
+  </body>
+</html>
diff --git a/core/src/components/item-sliding/test/open/item-sliding.e2e.ts b/core/src/components/item-sliding/test/open/item-sliding.e2e.ts
new file mode 100644
index 00000000000..0fa02f9e5c8
--- /dev/null
+++ b/core/src/components/item-sliding/test/open/item-sliding.e2e.ts
@@ -0,0 +1,129 @@
+import { expect } from '@playwright/test';
+import type { Locator } from '@playwright/test';
+import { configs, dragElementBy, test } from '@utils/test/playwright';
+
+const openSide = async (item: Locator, side: 'start' | 'end', direction: 'ltr' | 'rtl') => {
+  await item.evaluate((el: HTMLIonItemSlidingElement, side) => el.open(side), side);
+  const ratio = (side === 'end' ? 1 : -1) * (direction === 'rtl' ? -1 : 1);
+  await expect.poll(() => item.evaluate((el: HTMLIonItemSlidingElement) => el.getSlidingRatio())).toBe(ratio);
+  const itemElement = await item.locator('ion-item').elementHandle();
+  await itemElement!.waitForElementState('stable');
+};
+
+const slidingItem = `
+  <ion-item-sliding>
+    <ion-item><ion-label>Sliding item</ion-label></ion-item>
+    <ion-item-options side="start">
+      <ion-item-option onclick="document.querySelector('output').textContent = 'start'">Start</ion-item-option>
+    </ion-item-options>
+    <ion-item-options side="end">
+      <ion-item-option onclick="document.querySelector('output').textContent = 'end'">End</ion-item-option>
+    </ion-item-options>
+  </ion-item-sliding>
+`;
+
+// Programmatic open() in RTL is tracked separately in FW-3711.
+configs({ directions: ['ltr'] }).forEach(({ title, config }) => {
+  test.describe(title('item-sliding: switching open sides'), () => {
+    test.describe('single item', () => {
+      test.beforeEach(async ({ page }) => {
+        await page.setContent(
+          `
+          <ion-list>
+            ${slidingItem}
+          </ion-list>
+          <output></output>
+        `,
+          config
+        );
+      });
+
+      for (const side of ['start', 'end'] as const) {
+        const previousSide = side === 'start' ? 'end' : 'start';
+
+        test(`should allow option clicks after opening ${side} from ${previousSide}`, async ({ page }) => {
+          const item = page.locator('ion-item-sliding');
+          await openSide(item, previousSide, config.direction);
+          await openSide(item, side, config.direction);
+
+          await page.locator(`ion-item-options[side="${side}"] ion-item-option`).click();
+          await expect(page.locator('output')).toHaveText(side);
+        });
+
+        test(`should allow swiping closed after opening ${side} from ${previousSide}`, async ({ page }) => {
+          const item = page.locator('ion-item-sliding');
+          await openSide(item, previousSide, config.direction);
+          await openSide(item, side, config.direction);
+
+          await dragElementBy(
+            item,
+            page,
+            (await item.evaluate((el: HTMLIonItemSlidingElement) => el.getOpenAmount())) * 0.75
+          );
+          await expect.poll(() => item.evaluate((el: HTMLIonItemSlidingElement) => el.getOpenAmount())).toBe(0);
+        });
+
+        test(`should preserve disabled gestures when switching to ${side}`, async ({ page }) => {
+          const item = page.locator('ion-item-sliding');
+          await openSide(item, previousSide, config.direction);
+          await item.evaluate((el: HTMLIonItemSlidingElement) => (el.disabled = true));
+          await page.waitForChanges();
+          await openSide(item, side, config.direction);
+
+          await dragElementBy(
+            item,
+            page,
+            (await item.evaluate((el: HTMLIonItemSlidingElement) => el.getOpenAmount())) * 0.75
+          );
+          expect(
+            await item.evaluate(async (el: HTMLIonItemSlidingElement) => Math.abs(await el.getSlidingRatio()))
+          ).toBe(1);
+
+          await item.evaluate((el: HTMLIonItemSlidingElement) => (el.disabled = false));
+          await page.waitForChanges();
+          await dragElementBy(
+            item,
+            page,
+            (await item.evaluate((el: HTMLIonItemSlidingElement) => el.getOpenAmount())) * 0.75
+          );
+          await expect.poll(() => item.evaluate((el: HTMLIonItemSlidingElement) => el.getOpenAmount())).toBe(0);
+        });
+      }
+
+      test('should keep options clickable after repeated side changes', async ({ page }) => {
+        const item = page.locator('ion-item-sliding');
+        for (const side of ['start', 'end', 'start', 'end'] as const) {
+          await openSide(item, side, config.direction);
+        }
+
+        await page.locator('ion-item-options[side="end"] ion-item-option').click();
+        await expect(page.locator('output')).toHaveText('end');
+      });
+
+      test('should still finish closing before allowing a new swipe', async ({ page }) => {
+        const item = page.locator('ion-item-sliding');
+        await openSide(item, 'end', config.direction);
+        await openSide(item, 'start', config.direction);
+        await item.evaluate((el: HTMLIonItemSlidingElement) => el.close());
+        await expect(item).not.toHaveClass(/item-sliding-active-slide/);
+
+        await dragElementBy(item, page, config.direction === 'rtl' ? 150 : -150);
+        await expect
+          .poll(() => item.evaluate((el: HTMLIonItemSlidingElement) => el.getSlidingRatio()))
+          .toBe(config.direction === 'rtl' ? -1 : 1);
+      });
+    });
+
+    test('should still close the first item when another item opens', async ({ page }) => {
+      await page.setContent(`<ion-list>${slidingItem}${slidingItem}</ion-list><output></output>`, config);
+      const first = page.locator('ion-item-sliding').first();
+      const second = page.locator('ion-item-sliding').last();
+      await openSide(first, 'end', config.direction);
+      await openSide(second, 'start', config.direction);
+
+      await expect(first).not.toHaveClass(/item-sliding-active-slide/);
+      await second.locator('ion-item-options[side="start"] ion-item-option').click();
+      await expect(page.locator('output')).toHaveText('start');
+    });
+  });
+});